Bibliometric analysis on twin-twin transfusion syndrome between 2000-2025
A Bibliometric Evaluation of Global Publication Trends, Citation Analysis, and Research Collaborations
DOI:
https://doi.org/10.5281/zenodo.19242441Keywords:
Twin-Twin Transfusion Syndrome, bibliometric analysıs, articlesAbstract
Abstract
Background: Twin-to-Twin Transfusion Syndrome (TTTS) is a serious complication of the monochorionic twin pregnancies triggered by placental blood shunting. When left untreated, the fetal mortality rate is high and thus it is an issue of major significance in medical science. This study presents a bibliometric analysis of literature to evaluate research productivity and trends.
Methods: Articles and reviews, written in English, on TTTS published between 1 January 2020 and 15 August 2025 were identified using Web of Science Core Collection. Collaboration networks and keyword clusters were extracted using VOSviewer for analysis.
Results: A total of 1062 papers were found, 930 (87.5%) were research papers. The publication output grew significantly between 2015–2022, with its recent decrease.Most frequently cited papers were related to fetal heart disease, treatment, and outcome.
Conclusion: TTTS investigation developed remarkably in the past decade, especially in the aspect of diagnosis, therapy and its complications.
Downloads
References
1. Bamberg C, Hecher K. Twin-to-twin transfusion syndrome: Controversies in the diagnosis and management. Best Pract Res Clin Obstet Gynaecol. 2022;84:143-54.
2. Kajiwara K, Ozawa K, Wada S, Samura O. Molecular Mechanisms Underlying Twin-to-Twin Transfusion Syndrome. Cells. 2022;11(20):3268.
3. Spruijt MS, Lopriore E, J Steggerda S, Slaghekke F, Van Klink JMM. Twin-twin transfusion syndrome in the era of fetoscopic laser surgery: antenatal management, neonatal outcome and beyond. Expert Rev Hematol. 2020;13(3):259-67.
4. Society for Maternal-Fetal Medicine (SMFM), Miller RS, Miller JL, et al. Society for Maternal-Fetal Medicine Consult Series #72: Twin-twin transfusion syndrome and twin anemia-polycythemia sequence. Am J Obstet Gynecol. 2024;231(4):B16-B37.
5. Hessami K, Nassr AA, Sananès N, et al. Perinatal risk factors of neurodevelopmental impairment after fetoscopic laser photocoagulation for twin-twin transfusion syndrome: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2021;58(5):658-68.
6. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523-38.
7. Dhombres F, Bodenreider O. Trends in Fetal Medicine: A 10-Year Bibliometric Analysis of Prenatal Diagnosis. Stud Health Technol Inform. 2017;245:853-7.
8. Di Mascio D, Khalil A, D’Amico A, et al. Outcome of twin-twin transfusion syndrome according to Quintero stage of disease: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2020;56(6):811-820.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Aşkın Evren Güler, Sezin Oral Yıldız
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
